Grade: A (Strong Scientific Evidence)
Therapy	Specific therapeutic Use(s)
Sage	Mood enhancement
St. John's wort	Depressive disorder (mild-to-moderate)
Grade: B (Good Scientific Evidence)
Therapy	Specific therapeutic Use(s)
5-HTP	Depression
Grade: C (Unclear or Conflicting Scientific Evidence)
Therapy	Specific therapeutic Use(s)
Chasteberry	Premenstrual dysphoric disorder (PMDD)
Chromium	Bipolar disorder
Coleus	Depression and schizophrenia
Creatine	Depression
Folate	Depression
Ginkgo	Depression and seasonal affective disorder (SAD)
Guarana	Mood enhancement
Ignatia	Emotional disorders (emergency use)
Lavender	Depression
L-Carnitine	Depression
Melatonin	Bipolar disorder (sleep disturbances)
Omega-3 fatty acids, fish oil, alpha-linolenic acid	Bipolar disorder
Riboflavin	Depression
SAMe	Depression
St. John's wort	Depressive disorder (severe)
Valerian	Depression
Vitamin B6	Depression
Vitamin D	Seasonal affective disorder (SAD)
Traditional or Theoretical Uses which Lack Sufficient Evidence
Therapy	Specific therapeutic Use(s)
5-HTP	Bipolar disorder
Acerola	Depression
Aconite	Depression
Adrenal extract	Depression
Alpha-lipoic acid	Depression
Anise	Antidepressant
Arabinogalactan	Bipolar disorder
Ashwagandha	Depression
Bael fruit	Depressive disorder (major)
Bamboo	Post-natal depression
Black cohosh	Depression
Black currant	Depression
Black horehound	Depression
Bovine colostrum	Depression
Bupleurum	Depression
Calamus	Depression
Cardamom	Depression
Cat's claw	Depression
Chamomile	Post-natal depression
Chasteberry	Depression due to menopause
Chia	Depression
Choline	Bipolar disorder
Cinnamon	Antidepressant
Copper	Depression
Creatine	Bipolar disorder
Damiana	Depression
Dong quai	Emotional instability
Ephedra	Depression
Evening primrose oil	Post-natal depression
Flaxseed and flaxseed oil	Bipolar disorder
Germanium	Depressive symptoms
Ginger	Depression
Ginseng	Antidepressant
Glucosamine	Depression
Glyconutrients	Depression
Gotu kola	Antidepressant
Ground ivy	Hypochondria
Hoodia	Mood enhancement
Hops	Antidepressant
Hydrazine sulfate	Antidepressant
Hyssop	Depression
Ignatia	Bereavement
Iron	Depression
Kava	Depression
Khat	Depression
Lady's slipper	Depression (mild)
Lemon balm	Depression
Licorice	Depression
Maca	Depression
Mangosteen	Depression
Melatonin	Depression
Mistletoe	Depression
MSM	Mood enhancement
Mugwort	Antidepressant
Muira puama	Depression
Niacin	Depression
Noni	Depression
Nux vomica	Depression
Omega-3 fatty acids, fish oil, alpha-linolenic acid	Suicide prevention
Pantothenic acid	Depression
Perilla	Depression
Phosphates, phosphorus	Depression
Quercetin	Depression
Rhodiola	Depression
Riboflavin	Mood disorders
Saccharomyces boulardii	Depression
Salvia divinorum	Bipolar disorder
SAMe	Bipolar disorder
Selenium	Depression
Spirulina	Depression
Spleen extract	Emotional disorders
Taurine	Bipolar disorder
Thiamin	Depression
Thyme	Depression
Thymus extract	Depression (short-term)
Tribulus	Mood stimulant
Valerian	Hypochondria
Vitamin B12	Depression
Yohimbe bark extract	Depression